Top 8 Benzoyl Peroxide Lotions/Gels & Face Washes to Treat Acne 2025

• What Is Benzoyl Peroxide?

Benzoyl peroxide is known to be the most effective OTC acne treatment out there—you probably know it well from the ingredient label of nearly every pimple product you've ever used. Benzoyl peroxide is helpful for treating acne not only because it kills bacteria that contribute to acne, but because it helps prevent and clear out clogged pores. It's found in many different forms, from cleansers, lotions, creams, gels, and toner-like solutions.

• What Are the Possible Side Effects?

Benzoyl peroxide, like many acne medications, can cause dryness and peeling. Dry skin is the most common side effect.

The best way to combat this is to start off slowly, allowing your skin a chance to get used to the medication. Try using it every other day for a week or two. Using a good moisturizer will help too.

• The Best Benzoyl Peroxide Skincare Products

| CeraVe Acne Foaming Cream Cleanser

($16.99/150ml, up to 4% cashback at Walgreens)

The new CeraVe Acne Foaming Cream Cleanser is formulated to thoroughly dissolve dirt and excess oil, while clearing acne with 4% benzoyl peroxide. The formula also features hyaluronic acid to help retain your skin's natural moisture and niacinamide to provide you with soothing benefits, while allowing your skin to heal. Gentle on your skin, CeraVe Acne Foaming Cream Cleanser helps maintain the skin's barrier with three essential ceramides, leaving your skin feeling soft and comfortable, while reducing acne without dryness or flaking.

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| Differin Daily Deep Cleanser

($14.99/118ml, up to 2% cashback at CVS)

Formulated by dermatologists, this formula contains 5% benzoyl peroxide to treat acne for all skin types even oily and sensitive skin with less dryness and irritation compared to maximum strength formulas. At the same time, however, it also releases a gentle moisturizer meant to help balance your skin and prevent unwanted dryness. Reviewers repeatedly note how well it's helped clear their skin, and the affordable price doesn't hurt, either.

| PanOxyl Acne Foaming Wash

($11.99/156g, up to 4% cashback at Walgreens)

When it comes to body acne, skin can typically tolerate a higher percentage of benzoyl peroxide. PanOxyl's maximum strength 10% BP formula, the highest strength available without a prescription, is great to use in the shower to keep your chest and back acne under control. Recommended by dermatologists, the powerful cleansing wash kills acne-causing bacteria effectively to clear existing breakouts as well as helping to prevent new blemishes from forming when used as part of a daily routine.

| La Roche-Posay Effaclar Duo Dual Acne Treatment

($29.99/40ml, up to 8% cashback at La Roche-Posay)

La Roche-Posay Effaclar Duo Dual Action Acne Treatment with Benzoyl Peroxide is the only acne treatment available with micronized benzoyl peroxide (5.5%) and Lipo Hydroxy Acid (0.4%) to treat acne deep in the skin. 

Micronized benzoyl peroxide, with much smaller particles than the traditional formulations, penetrates the pores more deeply to destroy acne-causing bacteria and regulate oil. Lipohydroxy acid (LHA) has been shown to exfoliate six times more effectively, but far more gently, than the regular salicylic acid from which it's derived. 

| Paula's Choice Clear Regular Strength Daily Skin Clearing Treatment

($19/67ml, up to 7% cashback at Paula's Choice)

Unlike most benzoyl peroxide–based acne products, CLEAR Regular Strength Treatment contains no harsh or skin-aggravating ingredients that can cause more problems. Instead, you get a truly gentle formula medicated with the gold standard anti-acne ingredient benzoyl peroxide.

This lightweight formula eliminates pore-clogging bacteria with 2.5% benzoyl peroxide and keeps excess oil at bay. Soothing anti-irritants help to rapidly heal your skin and reduce the red marks caused by blemishes. Delivering a matte finish that's ideal for under-makeup application, it leaves you with the smooth, covetable complexion that you deserve.

| Obagi CLENZIderm M.D. Therapeutic Lotion

($84/47ml, up to 8% cashback at SkinStore)

Fight acne with this Obagi CLENZIderm Therapeutic Lotion. Formulated with 5% Benzoyl Peroxide, this product exfoliates your skin and eliminates bacteria that causes acne. SoluZyl Technology delivers medicated ingredients deep into pores to neutralize bacterial infections and stop pimples before they start. The formula also contains squalane to keep the complexion balanced to avoid excess oil production. 

| Clean & Clear Persa-Gel 10 Acne Medication

($5.97/28g, up to 4% cashback at Walmart)

Clean & Clear Persa-Gel 10 Acne Medication Spot Treatment with benzoyl peroxide targets pimples to help clear skin and prevent breakouts. This topical acne treatment gel is a maximum-strength acne spot treatment contains 10% benzoyl peroxide, the number-one pharmacist-recommended acne medication. The fragrance-free face gel quickly goes to work by releasing benzoyl peroxide deep in pores where pimples begin to effectively treat acne breakouts and help prevent them from occurring in the future. 

| Replenix BP Acne Gel 10% Spot Treatment

($30/57g, up to 5% cashback at Dermstore)

REPLENIX BP Acne Gel 10% Spot Treatment is a dermatologist-developed, scientifically formulated acne spot treatment for maximum potency and efficacy to eradicate blemishes. Utilizing the antibacterial properties of highly purified, medical-grade Benzoyl Peroxide USP to help clear existing blemishes and prevent future blemishes from forming.

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