Systane Ultra vs. Hydration PF vs. Lubricant Eye Gel Drops: Full Comparison & Verdict 2025

Systane Ultra vs. Hydration PF vs. Lubricant Eye Gel Drops

Systane Ultra Lubricant Eye Drops Review

Systane Ultra lubricant eye drops offer high performance dry eye symptom relief through a unique delivery system that provides soothing comfort and is clinically proven to deliver extended protection and relief that lasts. Systane Ultra immediately soothes irritated eyes no matter where you are. Systane Ultra is ideal for people suffering from mild to moderate dry eye symptoms.

• Fast relief

• Helps your eyes feel lubricated and refreshed 

• High-performance dry eye symptom relief 

• Extended protection for relief that lasts

• For aqueous dry eye relief

• Safe for use before and after contact lens wear (not a rewetting drop)

• Available in 25ct, 60ct, 4mL, 4mL twin pack, 10mL and 10mL twin pack 

• Preservative-free formula also available (preservative-free relief is perfect for sensitive eyes)

Ingredients

Where to Buy Systane Eye Drops?

You can go Walmart.com, Walgreens, Target, Rite Aid or Amazon.com to purchase Systane Eye Drops. Saving Tip: If you like online shopping, don't forget to sign up at Extrabux！(What is Extrabux) , then you can enjoy up to 30+% cashback on your purchase from Extrabux! Sign-Up Bonus: Free to join it & get $20 welcome bonus! Student Benefits：As long as you are a student at school, you can get a free whole year long VIP Card worth $199.

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SYSTANE HYDRATION PF Lubricant Eye Drops Review

SYSTANE HYDRATION PF Eye Drops provide long-lasting hydration and restore moisture to dry eyes with HydroBoost Technology.

Systane's most advanced preservative-free drop. Long lasting dry eye symptom relief without preservatives. No other preservative-free drops feature HydroBoost Technology, which lubricates the tear film. Common Dry Eye Symptoms include burning or stinging, fluctuating vision, irritation or watery eyes. 

• HydroBoost Technology (HP-Guar + Sodium Hyaluronate) gives an extra moisturizing boost of hydration

• Exclusive formula not available in store brands

• Preservative-free relief is perfect for sensitive eyes

• Safe for use before and after contact lens wear (not a rewetting drop)

• Indicated for use with aqueous dry eye 

• Ideal for patients using eye drops four or more times a day or for postsurgical patients (e.g., post-LASIK or post-cataract surgery with dry eye symptoms)

• Available in 30ct and 10ml Multidose Preservative-Free bottle

Ingredients

SYSTANE Lubricant Eye Gel Review

SYSTANE Lubricant Eye Gel offers a thick gel formulation to coat the eye with a soothing layer of dry eye symptom protection. Provides long-lasting nighttime protection while you sleep. 

• Thick gel formula provides a strong layer of protection

• Long-lasting relief from severe symptoms of dry eye

• Nighttime protection works while you sleep

• Remove contact lenses before use

• Available in 10g tube

Ingredients

Verdict: Which Should You Buy?

If you are sensitive to eye drops, then SYSTANE HYDRATION PF Lubricant Eye Drops is the first choice. Preservative-free relief is perfect for sensitive eyes. SYSTANE HYDRATION PF Lubricant Eye Drops is also ideal for patients using eye drops four or more times a day or for postsurgical patients (e.g., post-LASIK or post-cataract surgery with dry eye symptoms).

If you are not sensitive to eye drops, you can use SYSTANE ULTRA LUBRICANT EYE DROPS.

Finally, if you need nighttime soothing eye drops, then SYSTANE Lubricant Eye Gel is the best choice for you.

If you still not sure, you can take the dry eye quiz at Systane. Get personalized dry eye product recommendations and helpful tips to reduce symptoms and triggers that may impact your eyes. 

Systane Eye Drop Use Tips

1. For external use only. 

2. Do not use if this product changes color or becomes cloudy or if you are sensitive to any ingredient in this product. 

3. When using this product, do not touch tip of container to any surface to avoid contamination and replace cap after each use. 

4. Stop use and ask a doctor if you experience any of the following:

• eye pain

• changes in vision

• continued redness or irritation of the eye

• condition worsens or persists longer than 72 hours 

Keep out of reach of children. If swallowed, get medical help or contact a Poison Control Center right away.

Tips for Dry Eye

While there is no cure for dry eye, these simple tips and tricks can help ease those bothersome symptoms. 

1. Environmental Factors

Changing your environment isn’t always easy, but watching weather patterns can help you manage dry eye symptoms. Also avoid touching your eyes to prevent irritants from transferring to your eyes. Better yet, stay prepared by always carrying Eye Drops.

• Airports & Airplanes

Dry air in airports and planes can make your eyes feel dry or irritated. Be sure to pack your go-to dry eye symptom relief.

Bonus: Dehydration can cause dry eye symptoms to worsen, so remember to stay hydrated. If you tend to sleep on flights, wear an eye mask. And the overhead fan? Switch it off so it isn’t blowing in your face.

• Indoor Air (Heating & Cooling)

When temps change outside, air inside can make your eyes feel dry. Try running a humidifier and drink more water.

Bonus: If you’re waking up with dry eye symptoms, consider using a nighttime gel. It’s also good to turn your air-conditioner, heater or fan so it is not blowing into your eyes.

• Smoking

Quitting smoking and/or avoiding secondhand smoke can help prevent dry eye symptoms.

2. Diet & Supplements

We all know the importance of eating a healthy diet, but did you know that certain nutrients are a particularly good defense against dry eye symptoms?

• Omega-3 Oils

Omega-3 fats can improve function in the eyes’ meibomian glands, which produce the oily part of tears. Improved function of those glands can ease dry eye symptoms, so try incorporating supplements, fresh fish or walnuts into your diet.

• Vitamin A

Vitamin A is a powerful antioxidant that helps protect the surface of your eye. Eating foods such as carrots, sweet potatoes and spinach is a good way to help ease dry eye symptoms.

3. Other Healthy Lifestyle Changes 

• Blinking Exercises

Failing to blink regularly can contribute to your eyes drying out. Try to blink every five seconds, especially when staring at your computer screen or other digital device.

• Take Breaks

Reading or working at a computer can be a problem for people with dry eye. Try looking at something 20 feet away for 20 seconds every 20 minutes.

• Hydrate

The fluid in your eyes can be depleted if you’re dehydrated, so drink lots of water.

• Handwashing

Whether putting in drops or applying makeup, wash, rinse and dry your hands before touching your eyes.

• Exercise

Go for a nice walk or run. Exercise is good for you in many ways and can contribute to the health of your eyes too.

• Protective Eyewear

Exposure to wind and sun can make tears evaporate faster. When spending time outside, wear protective eyewear such as sunglasses and keep dry eye relief on hand.

• Eye Hygiene

Keep your eyelids clean and clear of debris using your go-to eyelid cleansing wipes. If you wear contact lenses, keep them clean and wear them only as prescribed.

• Warm Compress 

A damp washcloth or other warm compress can soothe dry eye and provide temporary relief.

In-Office Treatment

Talk to your eye doctor about whether you have evaporative dry eye and whether you'd be a good candidate for in-office Systane iLux treatment.

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