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La Roche Posay vs. Differin vs. ProactivMD Adapalene Gels: Which is Best for You?

La Roche Posay vs. Differin vs. ProactivMD Adapalene Gels: Which is Best for You?

    • Adapalene is the only FDA-approved retinoid available over the counter to be an alternative to Retin-A for those with sensitive skin. It's a strong acne fighter without the harsh skin irritation often caused by Retin-A, so patients can use this more frequently. Just like other retinoids, adapalene works to regulate skin cell turnover and improve acne as well as textural issues, plus brighten and even skin tone. Here, three cult favorites of adapalene treatments in the market are La Roche Posay Effaclar Adapalene Gel 0.1% Acne Treatment, Differin Adapalene Gel 0.1% Acne Treatment, and ProactivMD Adapalene Gel 0.1%. Which is best for you? Below, we will make a comparison to help you choose.

Cover Photo:editor lucia

  • The Difference & Reviews


| La Roche Posay Effaclar Adapalene Gel 0.1% Acne Treatment

Google Users Rating: 4.5/5

La Roche Posay: $30.99/45g (up to 8% cashback)

Walgreens: $29.99 (up to 4% cashback)

Dermstore: $30.99 (up to 7% cashback)

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Source:walmart.com

What Is It?

Effaclar Adapalene Gel 0.1% Retinoid Acne Treatment from La Roche-Posay is an FDA-approved prescription-strength retinoid acne treatment. This oil-free, fragrance-free acne treatment contains adapalene gel, a dermatologist recommended retinoid.

Active ingredients: 0.1% Adapalene

Texture:  The non-greasy, gel-like texture quickly absorbs into skin for a lightweight feeling that won't weigh skin down.

Fragrance: This Adapalene Gel doesn't contain any added fragrance or fragrant component, and it has no smell.

Review: As you may know, adapalene requires patience. It needs to be used consistently and it takes a couple months to start reaping the benefits. This product is great because it's fragrance free. Plus it has the added benefit of anti-aging prope rties.

One shopper said: "I use this on my chest and back acne and it has made a huge difference. My skin looks amazing and both breakouts and post-inflammatory pigmentation are nearly gone. There was a very brief period where my skin got slightly worse, but that is a typical side effect of retinoids so I wasn't too surprised. But my skin never felt too tight or dry, and no irritation or peeling either."

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| Differin Adapalene Gel 0.1% Acne Treatment

Google Users Rating: 4.5/5

Walmart: $14.97/15g (up to 4% cashback)

Walgreens: $15.99 (up to 4% cashback)

CVS: $17.49 (up to 2% cashback)

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Source:cvs.com

What Is It?

Differin is the first FDA-approved full prescription strength retinoid. This acne treatment is now available without a prescription. Differin treats the redness and inflammation associated with acne and helps prevent pimples, blackheads, and clogged pores before they occur. This product also reduces redness and inflammation caused by acne and restores skin's tone and texture by treating and clearing acne. 

Active ingredients: 0.1% Adapalene

Texture: This product is a lightweight gel that, thankfully, doesn't leave any sticky or tacky residue after application. When you're experiencing a breakout, you want to apply a bit more to ensure the product is working. That isn't necessary here—a pea-sized amount does the trick. 

Fragrance: It doesn't have any added fragrance or fragrant components, and it has no scent.

Review: Differin, the first prescription-strength retinoid (adapalene) available OTC, this cult-favorite product is especially effective for a range of skin concerns from acne and discolorations to fine lines and wrinkles. Be sure to use this one with a gentle moisturizer, as it acts as more of a treatment. If you experience irritation, wash your face first, then apply a moisturizer and follow up with the Differin on top at night, recommends. That gives you a barrier in between your skin and the Differin, improving tolerability.

The Difference with La Roche Posay Effaclar Adapalene Gel Treatment:

Both adapalene gels are very straight-to-the-point products, and besides the active ingredient, they just contain a few more carbomers to provide thickness and viscosity to the formula and solvents to keep it stable for a long time.

But La Roche Posay's Adapalene Gel has a smoother texture than Differin that spreads easily on the skin.

Differin is a little stiffer and doesn't spread as easily as La Roche Posay because of the different carbomer.


| ProactivMD Adapalene Gel 0.1%

Google Users Rating: 4.3/5

Walmart: $31.95/45g (up to 4% cashback)

eBay US: $35.99 (up to 4.6% cashback)

Amazon: $35.99

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Source:gosupps.com

What Is It?

Adapalene treats and prevents acne, which helps restore your skin's natural tone and texture. With this 30-day supply of Adapalene, you'll be able to treat and clear your acne with the power of Rx. Please note, additional moisture and sun protection are highly recommended with the use of ProactivMD.

Active ingredients: 0.1% Adapalene

Texture: It has a nice, easy-to-spread texture. It absorbs quickly and is very gentle to skin.

Fragrance: No funny smell.

Review: The Adapalene gel help with drying up the cystic acne which pops up during those pesky times. It does cause dryness, but it helps dry the acne, so dermatologists suggest using a moisturizer and letting it dry before using this product - and then, use it at night and only use small amounts, and every-other-day.

One customer reviewed: "I've tried all sorts of Proactiv products over the years and this has been the only product that honestly worked! It has cleared my acne, prevented new ones from forming, and has also lighten my stubborn post acne hyperpigmentation. My face has never been this clear before. I will say that it does dry out your skin, so I'd highly suggest applying spf moisturizer after it settles."

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2023-01-11 00:561136